解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a bis-benzodioxolylindolinone (azoffluxin) that synergizes with fluconazole against C. auris. Azoffluxin e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20183-3
更新日期:2020-12-22 00:00:00
abstract::Overcoming the restricted axonal regenerative ability that limits functional repair following a central nervous system injury remains a challenge. Here we report a regenerative paradigm that we call enriched conditioning, which combines environmental enrichment (EE) followed by a conditioning sciatic nerve axotomy tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20179-z
更新日期:2020-12-21 00:00:00
abstract::In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not know...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20157-5
更新日期:2020-12-18 00:00:00
abstract::Bulk photovoltaic effect (BPVE), featuring polarization-dependent uniform photoresponse at zero external bias, holds potential for exceeding the Shockley-Queisser limit in the efficiency of existing opto-electronic devices. However, the implementation of BPVE has been limited to the naturally existing materials with b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20115-1
更新日期:2020-12-17 00:00:00
abstract::Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20039-w
更新日期:2020-12-15 00:00:00
abstract::Genetic mutations predispose the serine protease inhibitor α1-antitrypsin to misfolding and polymerisation within hepatocytes, causing liver disease and chronic obstructive pulmonary disease. This misfolding occurs via a transiently populated intermediate state, but our structural understanding of this process is limi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20147-7
更新日期:2020-12-11 00:00:00
abstract::Materials hosting magnetic skyrmions at room temperature could enable compact and energetically-efficient storage such as racetrack memories, where information is coded by the presence/absence of skyrmions forming a moving chain through the device. The skyrmion Hall effect leading to their annihilation at the racetrac...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20025-2
更新日期:2020-12-11 00:00:00
abstract::The transcriptional regulatory network (TRN) of Bacillus subtilis coordinates cellular functions of fundamental interest, including metabolism, biofilm formation, and sporulation. Here, we use unsupervised machine learning to modularize the transcriptome and quantitatively describe regulatory activity under diverse co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20153-9
更新日期:2020-12-11 00:00:00
abstract::Environmental metabolomes are fundamentally coupled to microbially-linked biogeochemical processes within ecosystems. However, significant gaps exist in our understanding of their spatiotemporal organization, limiting our ability to uncover transferrable principles and predict ecosystem function. We propose that a the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19989-y
更新日期:2020-12-11 00:00:00
abstract::Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20192-2
更新日期:2020-12-10 00:00:00
abstract::Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20059-6
更新日期:2020-12-10 00:00:00
abstract::Analyzing scattered wave to recognize object is of fundamental significance in wave physics. Recently-emerged deep learning technique achieved great success in interpreting wave field such as in ultrasound non-destructive testing and disease diagnosis, but conventionally need time-consuming computer postprocessing or ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19693-x
更新日期:2020-12-09 00:00:00
abstract::The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient het...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20139-7
更新日期:2020-12-09 00:00:00
abstract::Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20074-7
更新日期:2020-12-09 00:00:00
abstract::C-Analogues of the canonical N-nucleosides have considerable importance in medicinal chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic biology. Although well established for synthesis of N-nucleosides, biocatalytic methods are lacking in C-nucleoside synthetic chemistry. Here, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20035-0
更新日期:2020-12-08 00:00:00
abstract::The central melanocortin system plays a fundamental role in the control of feeding and body weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) also regulate overall glucose homeostasis via insulin-dependent and -independent pathways. Here, we report that a subset of ARC POMC ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20160-w
更新日期:2020-12-08 00:00:00
abstract::The cell cytosol is crowded with high concentrations of many different biomacromolecules, which is difficult to mimic in bottom-up synthetic cell research and limits the functionality of existing protocellular platforms. There is thus a clear need for a general, biocompatible, and accessible tool to more accurately em...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20124-0
更新日期:2020-12-08 00:00:00
abstract::Domesticator-domesticate relationships are specialized mutualisms where one species provides multigenerational support to another in exchange for a resource or service, and through which both partners gain an advantage over individuals outside the relationship. While this ecological innovation has profoundly reshaped ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19958-5
更新日期:2020-12-07 00:00:00
abstract::Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20127-x
更新日期:2020-12-07 00:00:00
abstract::Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch's reaction, high-throughput methods and polymer chemistry. A ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20027-0
更新日期:2020-12-04 00:00:00
abstract::Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20007-4
更新日期:2020-12-04 00:00:00
abstract::The importance of singlet oxygen (1O2) in the environmental and biomedical fields has motivated research for effective 1O2 production. Electrocatalytic processes hold great potential for highly-automated and scalable 1O2 synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalyti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20071-w
更新日期:2020-12-04 00:00:00
abstract::Pulses of tree mortality caused by drought have been reported recently in forests around the globe, but large-scale quantitative evidence is lacking for Europe. Analyzing high-resolution annual satellite-based canopy mortality maps from 1987 to 2016 we here show that excess forest mortality (i.e., canopy mortality exc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19924-1
更新日期:2020-12-03 00:00:00
abstract::Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic polyketide with antib...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19984-3
更新日期:2020-12-03 00:00:00
abstract::Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19915-2
更新日期:2020-12-02 00:00:00
abstract::The three-dimensional structure of chromosomes plays an important role in gene expression regulation and also influences the repair of radiation-induced DNA damage. Genomic aberrations that disrupt chromosome spatial domains can lead to diseases including cancer, but how the 3D genome structure responds to DNA damage ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20047-w
更新日期:2020-12-02 00:00:00
abstract::How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19936-x
更新日期:2020-12-02 00:00:00
abstract::Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) is now common practice in structural biology. However, it is most of the time applied to rather small oligomeric complexes. Here, we report on the use of HDX-MS to investigate conformational differences between the human standard 20S (std20S) and immuno...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19934-z
更新日期:2020-12-01 00:00:00
abstract::Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19880-w
更新日期:2020-12-01 00:00:00
abstract::Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19588-x
更新日期:2020-11-30 00:00:00
abstract::Phylogenetic trees are essential for studying biology, but their reproducibility under identical parameter settings remains unexplored. Here, we find that 3515 (18.11%) IQ-TREE-inferred and 1813 (9.34%) RAxML-NG-inferred maximum likelihood (ML) gene trees are topologically irreproducible when executing two replicates ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20005-6
更新日期:2020-11-30 00:00:00
abstract::Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19947-8
更新日期:2020-11-30 00:00:00
abstract::Tunneling is a fundamental quantum process with no classical equivalent, which can compete with Coulomb interactions to give rise to complex phenomena. Phosphorus dopants in silicon can be placed with atomic precision to address the different regimes arising from this competition. However, they exploit wavefunctions r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19835-1
更新日期:2020-11-30 00:00:00
abstract::Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19527-w
更新日期:2020-11-30 00:00:00
abstract::Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for fut...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19828-0
更新日期:2020-11-27 00:00:00
abstract::By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19820-8
更新日期:2020-11-27 00:00:00
abstract::Naturally-occurring thermal materials usually possess specific thermal conductivity (κ), forming a digital set of κ values. Emerging thermal metamaterials have been deployed to realize effective thermal conductivities unattainable in natural materials. However, the effective thermal conductivities of such mixing-based...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19909-0
更新日期:2020-11-27 00:00:00
abstract::Human activities are transforming grassland biomass via changing climate, elemental nutrients, and herbivory. Theory predicts that food-limited herbivores will consume any additional biomass stimulated by nutrient inputs ('consumer-controlled'). Alternatively, nutrient supply is predicted to increase biomass where her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19870-y
更新日期:2020-11-27 00:00:00
abstract::China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19854-y
更新日期:2020-11-27 00:00:00
abstract::The biological pump transports organic carbon produced by photosynthesis to the meso- and bathypelagic zones, the latter removing carbon from exchanging with the atmosphere over centennial time scales. Organisms living in both zones are supported by a passive flux of particles, and carbon transported to the deep-sea t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19875-7
更新日期:2020-11-27 00:00:00